The strength of tablet can be increased the next time, if the lower dose does not have the desired response and you had no significant side effects.
Premature Ejaculation Medications
Efficacy and safety of dapoxetine in men with premature ejaculation and concomitant erectile dysfunction treated with a phosphodiesterase type 5 inhibitor: randomized, placebo-controlled, phase III study. Full title A Prospective, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study of the Efficacy and Safety of Dapoxetine in Men With Premature Ejaculation and Concomitant Erectile Dysfunction Treated With a Phosphodiesterase-5 Inhibitor COUPLE: COncomitant Use of PriLigy in Men Treated for Erectile Dysfunction A Prospective, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study of the Efficacy and Safety of Dapoxetine in Men With Premature Ejaculation and Concomitant Erectile Dysfunction Treated With a Phosphodiesterase-5 Inhibitor COUPLE: COncomitant Use of PriLigy in Men Treated for Erectile Dysfunction Sponsor organisation Janssen Cilag International N.V. Research summary Premature ejaculation (PE)in men with underlying erection problems affects a substantial number of men. The standard treatment for erection problems is the use of drugs called PDE-5 inhibitors (for example, Viagra, Cialis and Levitra). At present it is not clear whether adding the new drug dapoxetine in men whose underlying erectile dysfunction (ED) has been successfully treated will improve their symptoms of premature ejaculation.
About the reviewer
Dapoxetine is the only drug in its class which can be used on an "as needed" basis. Dapoxetine, when administered 1 to 3 hours before anticipated intercourse, is generally well tolerated and results in a significant improvement in the time to ejaculation in men with PE. The primary aim of the current study is to assess the effectiveness of 12 weeks treatment with one of two doses of dapoxetine (taken on an "as needed" basis) compared to placebo (dummy treatment) in prolonging the time to ejaculation in men with PE and ED who are already being treated with a PDE-5 inhibitor. A total of approximately 656 men will take part in a number of study sites internationally. Premature ejaculation (PE)in men with underlying erection problems affects a substantial number of men.
Priligy side effects
REC name East Midlands - Nottingham 2 Research Ethics Committee East Midlands - Nottingham 2 Research Ethics Committee Date of REC Opinion 6 Apr 2010 Take 1 tablet 1-3hrs before sex Works for 8 out of 10 men Take 1 tablet 1-3hrs before sex and it can triple the time it takes to ejaculate. Take 1 tablet 1-3hrs before sex. Priligy can be taken with or without food. You should not consume alcohol when you use Priligy. Never take more than one tablet within a 24hr period. You should not take a dose more than once every 24 hours and do not take it every day.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Priligy Generic Dapoxetine | 60mg | 60 + 8 Pills | 183.06€ 174.34€ | |
| Cialis Generic | 2.5mg | 10 Pills | 28.51€ 27.15€ | |
| Priligy Generic Dapoxetine | 60mg | 10 Pills | 47.63€ 45.36€ | |
| Priligy Generic Dapoxetine | 60mg | 20 + 4 Pills | 77.31€ 73.63€ | |
| Cialis Original | 20mg | 48 + 4 Pills | 224.69€ 213.99€ | |
| Priligy Generic Dapoxetine | 60mg | 120 + 10 Pills | 341.26€ 325.01€ | |
| Viagra Super Active | 100mg | 180 + 20 Pills | 280.97€ 267.59€ | |
| Priligy Generic Dapoxetine | 60mg | 90 + 10 Pills | 265.64€ 252.99€ | |
| Cialis Generic | 10mg | 10 Pills | 31.41€ 29.91€ | |
| Priligy Generic Dapoxetine | 60mg | 180 + 10 Pills | 494.76€ 471.20€ | |
| Kamagra | 100mg | 180 + 6 Pills | 436.79€ 415.99€ | |
| Priligy Generic Dapoxetine | 60mg | 30 + 6 Pills | 106.65€ 101.57€ | |
| Viagra Generic | 50mg | 90 + 6 Pills | 107.37€ 102.26€ |
It is possible that grapefruit juice will cause the dapoxetine (Priligy) to stay in your system longer, so you should wait 24 hours after drinking grapefruit juice before taking dapoxetine.
More info about Priligy
Checks are carried out within the Priligy online consultation. The license for dapoxetine states that Viagra (sildenafil), Cialis (tadalafil), and other erectile dysfunction drugs should not be used together with Priligy as there is a risk of very low blood pressure. If you suffer from both erectile dysfunction (ED) and premature ejaculation (PE) try treatment for ED first and if you still have PE problems discuss this with your regular doctor who may be able to prescribe these together following a more in depth review. Priligy (dapoxetine) was developed after it was realised that a side effect of taking SSRI antidepressants was to prolong erections. It was specifically designed as a short acting medication rather than an antidepressant but acts in the same way to increase serotonin levels in the brain, which delays ejaculation. Grapefruit juice is a weak inhibitor of CYP3A4 gut wall metabolism, which can lead to a rise in levels of many drugs in your blood. Men usually get on well with dapoxetine (Priligy). The most common side effects are dizziness dapoxetine tadalafil tablets due to lower blood pressure, nausea, and headache.
| Study/Source | Efficacy Rate | Satisfaction Level | Notes |
|---|---|---|---|
| Clinical Trial (2022) | 70-80% | High | Significant improvement in ejaculation latency |
| Patient Surveys (2023) | 75% | Very satisfied | Many report improved sexual confidence |
| Meta-Analysis (2021) | 65-85% | Varies | Effectiveness depends on dosage and severity of PE |
| Long-Term Use Reports (2024) | Maintains benefit | Consistent | Most users report sustained effect over time |
The full list of side effects is in the patient information leaflet.
- Dapoxetine has been shown to significantly increase ejaculatory latency time.
- It is not intended to treat all aspects of sexual dysfunction.
- Use of dapoxetine may require dose adjustments based on side effects.
- The medication should be stored safely out of children's reach.
- Monitoring response and side effects enhances safe use of dapoxetine.
- Dapoxetine should be used only as part of a broader treatment plan.
You are more likely to have side effects if taking alcohol, recreational drugs (such as LSD, heroin, methadone), or sleeping tablets at the same time as Priligy.
- Some men may experience mood changes or irritability with dapoxetine.
- Alcohol use can increase the risk of side effects when taking dapoxetine.
- Dapoxetine is not approved for use in women or children.
- Store dapoxetine in a cool, dry place away from children.
- Always report any unusual or severe side effects to your doctor.
- It is important to get a medical assessment before starting dapoxetine.
There are some interactions with other drugs and some herbal remedies.
Why Should You Choose Steris Healthcare For Dapoxetine ?
It is washed out of the system within around 20 hours (half-life approximately 1.5 hours) and has no antidepressant effect. There are two strengths of dapoxetine (Priligy) tablets: 30mg and 60mg. You should start with the lower 30mg strength, taking the tablet 1-3 hours before sexual intercourse. Swallow the tablet whole, with a full glass of water. It can be taken with or without food. The online consultation questionnaire checks if your medication is unsuitable to take with Priligy.
What are the most common side effects of Priligy?
It is usually related to stress and psychological factors rather than a physical problem. There are a variety of ways to help. Doctors define premature ejaculation as ejaculation in less than 2 minutes from penetration. However, if you ejaculate with very little stimulation, or before you want, and it is leading to relationship difficulties, you may benefit from treatment. There is medication available - dapoxetine (Priligy) - but there are also physical treatments such as extra thick condoms or anaesthetic (numbing) creams and sprays, and condoms pre-coated with numbing gel, which reduce penile sensitivity.
Estimated impact for the NHS
These can be bought in many pharmacies without the need for a prescription. As premature ejaculation is often linked to stress and psychological factors, psychological therapies can help. See NHS - Ejaculation problems or the book Coping with Premature Ejaculation: How to Overcome PE, Please Your Partner, and Have Great Sex (2004) by Michael E. Metz. There are a few medical conditions where it would be unsafe to take Priligy. Priligy is only licensed for use by men aged between 18 and 64 years.
- Dapoxetine's effectiveness peaks when taken on an empty stomach.
- It is classified as a selective serotonin reuptake inhibitor (SSRI).
- The medication’s half-life is short, leading to quick clearance from the system.
- Dapoxetine does not cure premature ejaculation but manages symptoms temporarily.
- Possible temporary side effects include mild nausea and dizziness.
- Do not exceed the recommended dose to avoid adverse effects.
The effectiveness and safety of Priligy has not been established in patients aged 65 years and over.
| Parameter | Guideline |
|---|---|
| Recommended Dose | 30 mg to start; possible increase to 60 mg if needed |
| Timing Before Sex | 1 to 3 hours prior |
| Frequency of Use | No more than once per day |
| Consumption with Food | Usually taken with or without food, consistency advised |
| Alcohol Interaction | Avoid alcohol; increases side effects |
| Precautions | Not suitable for certain health conditions, consult doctor |
Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency, or glucose-galactose malabsorption should not take dapoxetine (Priligy). Most men benefit from dapoxetine (Priligy), but psychological therapies and direct physical treatments can be used at the same time and may increase the benefit.
Is there anyone who can't take dapoxetine (Priligy)?
Priligy contains the active ingredient dapoxetine, which is a selective serotonin reuptake inhibitor (SSRI). It works by boosting the levels of serotonin in the body, causing a delayed reaction in the areas of the brain that cause ejaculation. This means it takes longer to reach orgasm. The most common side effects are nausea, dizziness, headache, fainting and diarrhoea. If you feel dizzy or faint after taking Priligy then you should not drive, operate heavy machinery or undertake hazardous activities.
Competing interests
For full information on side effects and correct use, see the patient information leaflet. If any side effects cause you concern, contact us via your account. Priligy is most effective 1-3hrs after it is taken, but can sometimes retain its effects for up to 12 hours. These men should notice a dapoxetin sildenafil doubling or tripling of the time their erection lasts before ejaculation. Priligy is not a cure and will only work when you take it.
What Is the Role of Ejaculation Latency in the Diagnosis of Premature Ejaculation and Does the Ejaculation Latency Threshold Matter?
Priligy is only licensed in men between the ages of 18 and 64 who have had PE for at least six months. This means men who ejaculate in less than two minutes of penetration. It should not be taken by men who have heart disease, issues with blood clotting, those who have a tendency to faint or in those who take certain medicines. This is because more serious side effects can occur. As is true of all medication, Priligy can interact with other medicines. Priligy was first launched in the UK in 2013 and remained under patent until October 2025, so only the drug company Menarini could produce and sell the medicine.
Pathophysiology of PE
Generally Priligy should not be mixed with antidepressants, blood thinners, medicine taken for kidney or liver conditions, and by those who are prone to excessive dehydration.There are additional medicines that interact with Priligy. This is why it's important that you let us know which prescription, over-the-counter medicines and recreational drugs you are taking so that we can prescribe Priligy safely. Do not consume alcohol with Priligy, as this can make some side effects worse and affect how well the treatment works.Priligy (dapoxetine) is a temporary solution, not a cure. Due to the complex nature of why premature ejaculation happens, Priligy is unable to treat the underlying causes of PE. It works best when combined with behavioural techniques and, in some cases, counselling or psychotherapy.
Intravaginal ejaculatory latency time (IELT)
Some men find counselling or hypnotherapy helpful as a means of exploring and dapoxetine spain treating psychological causes for PE. Others use behavioural techniques to manage their PE with success.We can also prescribe EMLA, which is an anaesthetic cream applied to the penis. It makes nerve endings less sensitive, and can delay the time it takes to ejaculate. How do I know if I have premature ejaculation? What treatment is available for premature ejaculation?
Derivative Synchronous Fluorescence Spectroscopy for the Simultaneous Determination of Dapoxetine Hydrochloride and Vardenafil in Binary Mixtures
Can I take erectile dysfunction drugs with dapoxetine (Priligy)? What are the side effects of dapoxetine (Priligy)? How can I reduce the risk of side effects of dapoxetine (Priligy)? Premature ejaculation (PE) is actually quite common. Up to 30% of men suffer with PE problems at some time in their life. When the patent expired, lower cost generic/unbranded versions became available and Menarini decided to no longer market Priligy. Dapoxetine is available on prescription in some NHS health authority areas, usually after specialist referral and advice - please check with your local GP surgery.
| Attribute | Description | Notes |
|---|---|---|
| Purpose | Delays ejaculation time during intercourse | Often prescribed for PE |
| Typical Dosage | 30 mg to 60 mg | Taken 1-3 hours before sex |
| Onset of Action | Within 1-3 hours | Peak effect approximately 1 hour after intake |
| Duration of Effect | 2 to 4 hours | Varies per individual |
| Common Side Effects | Nausea, dizziness, headache | Usually mild |
| Contraindications | Use with MAO inhibitors, severe cardiac issues | Consult doctor before use |
NHS doctors will also usually be able to write private prescriptions for dapoxetine (charges will apply).
- Differential diagnosis: rule out erectile dysfunction, hormonal issues.
- Physical exam is part of assessment but often normal in PE.
- Validated questionnaires (e.g., PEDT) aid in diagnosis and monitoring.
- Treatment goal: satisfactory sexual experience for both partners.
- Dapoxetine addresses the biological, not solely psychological, aspect.
- May reduce performance anxiety secondary to PE.
- Prescribing guidelines emphasize starting at lowest effective dose.
- Long-term data on intermittent use over years is limited.