); the Department of Urology, University of Virginia, Charlottesville (W.D.S. Select the format you want to export the citation of this publication. Multi-view semi-supervised adversarial attention network for drug repurposing, Computer Methods and Programs in Biomedicine, 282, (109406), (2026). Multi‐Target Mechanisms of Moroccan Aphrodisiac Plants: An Integrative Computational and Phytochemical Investigation, Food Science & Nutrition, 14, 5, (2026).

5.2 Worsening Pulmonary Vascular Occlusive Disease

Auerbach, Newport Beach, Calif.; A.L. Burnett, Baltimore; R. Castellanos, Fort Myers, Fla.; L. Charles, Stratford, N.J.; F. Eid, New York; R.

Therapies for Erectile Dysfunction

Feldman, Waterbury, Conn.; W. Fitch III, San Antonio, Tex. ; T. Garland, Lawrence, N.J.; M. Gittelman, North Miami, Fla.; D. Artificial intelligence in drug research and development: a review of methods and applications in drug repurposing, Briefings in Bioinformatics, 27, 3, (2026).

Patients should avoid grapefruit or grapefruit juice while taking sildenafil tablets.
Consult your doctor if you experience persistent pain or vision changes.
Sildenafil tablets can be part of a broader treatment plan including lifestyle changes.

Endocrine-metabolic crosstalk in erectile dysfunction: mechanistic insights and therapeutic implications, International Journal of Impotence Research, (2026). Therapeutic applications of phosphodiesterase inhibitors in male reproductive health: narrative review, Sexual Medicine Reviews, 14, 2, (2026). Oral suspension versus tablet sildenafil for erectile dysfunction: a prospective multicenter comparative study on patient satisfaction, International Journal of Impotence Research, (2026).

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Low‐intensity shockwave therapy for erectile dysfunction: An abridged Cochrane review, BJU International, 137, 6, (949-957), (2026).

Sildenafil tablets can cause a sudden drop in blood pressure if combined with nitrates.
Proper hydration helps ensure the effectiveness of sildenafil tablets.
Reading the patient information leaflet helps understand the correct use of sildenafil.

Current state of the problem, Andrology and Genital Surgery, 25, 4, (33-40), (2026). Emerging Trends and Research Focus in Erectile Dysfunction Treatment: A 1993–2023 Bibliometric Analysis, Andrologia, 2026, 1, (2026). Age > 65 years, hepatic impairment: 25 mg Severe renal impairment (CrCl < 30 ml/min): 25 mg Moderate hepatic impairment: initial 5 mg, max 10 mg Mild, moderate, severe renal impairment: No adjustment Mild or moderate hepatic impairment: max 10 mg once daily Moderate renal impairment: initial 5 mg once daily, max 10 mg every 48 hours Severe renal impairment (CrCl < 30 ml/min) on hemodialysis: max 5 mg Sildenafil is used to treat erectile dysfunction (also called sexual impotence). Sildenafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly.

Country	Status	Notes
USA	Approved by FDA	Prescription required
EU countries	Approved and regulated	Prescription necessary
Some developing countries	Varies; often available OTC	Legality depends on local laws

The penis is one of the areas where this enzyme works. Erectile dysfunction is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. When a man is sexually stimulated, his body's normal response is to increase blood flow to his penis to produce an erection. By controlling the enzyme, sildenafil helps to maintain an erection after the penis is stroked. Without physical action to the penis, such as that occurring during sexual intercourse, sildenafil will not work to cause an erection. Sildenafil is also used in both men and women to treat the symptoms of pulmonary arterial hypertension. This is a type of high blood pressure that occurs between the heart and the lungs. When hypertension occurs in the lungs, the heart must work harder to pump enough blood through the lungs. Sildenafil works on the PDE5 enzyme in the lungs to relax the blood vessels. This will increase the supply of blood to the lungs and reduce the workload of the heart. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make.

2.1 Recommended Dosage in Adults

Oral therapy permits discreet administration and is less invasive than some other treatment options, including injections into the corpus cavernosum, transurethral drug delivery, and prosthesis implantation. Goldstein, Lue, Padma-Nathan, Rosen, and Steers have served as consultants to Pfizer, manufacturer of sildenafil, as well as to other companies making products for the treatment of erectile dysfunction. We are indebted to all the investigators who participated in the trials; to Dr. Ian Osterloh and Dr. David Cox of Pfizer for their help with the study design and logistics; to Dr.

Are you currently using Sildenafil (Viagra, Revatio)?

Michael Collins and Dr. Michael Smith of Pfizer for their assistance with data analysis; and to Dr. Patricia Leinen and Dr. Michael Sweeney for aid in the preparation of the manuscript. The other members of the Sildenafil Study Group are S. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines.

How to Increase Bed-Time with Ayurveda Medicines

Br J Clin Pract 1997;51:99-103 Any commercial reuse of NEJM Group content requires permission. From the Department of Urology, Boston University Medical Center, Boston (I.G. ); the Department of Urology, University of California, San Francisco (T.F.L. ); the Department of Urology, University of sildenafil gel Southern California, Los Angeles, and the Male Clinic, Santa Monica, Calif. (H.P.-N.); the Department of Psychiatry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, N.J. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

8.2 Lactation

Tuttle, Lexington, Ky.; G. Wells, Birmingham, Ala.; C. White, Mobile, Ala.; J. Young, Laguna Hills, Calif.; and N. Zinner, Torrance, Calif.

Drugs Affecting Gastric Acidity

Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. Sex-ual behavior in the human male. Efficacy and safety of intracavernosal alprostadil in men with erectile dysfunction. Treatment of men with erectile dysfunction with transurethral alprostadil. Clinical Guidelines Panel on Erectile Dysfunction: summary report on the treatment of organic erectile dysfunction. Appropriate studies have not been performed on the relationship of age to the effects of sildenafil in children younger than 1 year of age. Safety and efficacy have not been established.

2.2 Recommended Dosage in Pediatric Patients

Gleason, Tucson, Ariz.; F. Govier, Seattle; L. Hoffman, Gurnee, Ill.; J.M. Kaufman, Aurora, Colo.; I. Klimberg, Ocala, Fla.; V.

Sildenafil side effects

Longo, New London, Conn.; T. Malloy, Philadelphia; A. McCullough, New York; J. McMurray, Huntsville, Ala.; D.F. ; J Susset, Providence, R.I.; J. Sildenafil should never be used in children for erectile dysfunction. In general, sildenafil should not be used for pulmonary arterial hypertension in children, especially for chronic use. Use of sildenafil oral film is not indicated for use in the pediatric population. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of sildenafil in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving sildenafil. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended.

Guideline	Description	Rationale
Take on an empty stomach	Preferably 1 hour before sexual activity	Slower absorption on high-fat meals
Avoid heavy alcohol consumption	Can impair effectiveness or cause side effects	Alcohol can cause vasodilation and hypotension
Do not exceed recommended dose	To prevent adverse effects	Overdose can cause serious health issues

Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur.

13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility

Sildenafil, a novel effective oral therapy for male erectile dysfunction. Br J Urol 1996;78:257-261 Rosen, RC, Riley, A, Wagner, G, Osterloh, IH, Kirkpatrick, J, Mishra, A. The International Index of Erectile Function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Riley, AJ, Athanasiadis, L. Impotence and its non-surgical management. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases.

12.2 Pharmacodynamics

Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med 1992;326:90-94 Andersson, K-E, Wagner, G. Physiology of penile erection. The role of nitric oxide in the physiology of erection. Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Abnormal penis, including a curved penis or birth defects of the penis—Chance of problems occurring may be increased and this medicine should be used with caution in these patients.